Evaluation of plasma lipid peroxidation and antioxidants activity in Plasmodium falciparum infected subjects

Abstract

Plasmodium falciparum remains the deadliest among the malaria causing species of protozoan found mostly in female anopheles mosquito. Malaria is a serious health challenge in sub Saharan Africa. This protozoan destroy red blood cells causing anemia which complicate major tissues in the body. This research was done to evaluate the level of lipid peroxidation and antioxidant profile in the plasma of plasmodium falciparum infected subjects. The study includes 50 plasmodium falciparum infected malaria patients as test and 50 apparently healthy subjects without plasmodium falciparum infection as control group from the outpatient Department of Wesley Guide Hospital, Ilesa, Osun State. An amount of blood (5mls) was taken from both test and control and processed to obtain the plasma which was stored at room temperature before analysis. The activity of SOD, GSH, GPx and CAT and lipid peroxidation level were determined in the plasma of both test and control subjects using appropriate method. The study revealed no significant change (p