Evaluation of von willbrand factor in severely affected COVID-19 patients

Abstract

Background: Severely affected COVID-19 cases with respiratory rate > 30 cycle/minute, pneumonia features and oxygen saturation < 90% may have high VWF due to endothelial cell damage.Aims of the study: Evaluation of Von Willbrand Factors antigen levels. Finding correlations among (VWF), D dimer and oxygen saturation.Methods: This cross sectional study was conducted on 50 PCR positive patients were severely affected and admitted to hospitals (Al-Imamain Kadhimian medical city, IBN AL-Khateeb hospital and Dar Al Salam 1field hospital) from January till May 2021. The leftover of plasma samples anticoagulated with trisodium citrate were used for evaluation of VWF: Ag by VIDAS system using VWF kit with ELFA technique. Other parameters were taken from patients files.Results: The study included 33 males and 17 females with age range of (34-86) years. Mean of VWF, D dimer were high. Oxygen saturation was significantly low and inversely correlated with VWF. There were statistically significant correlations (P Value < 0.05) between VWF and D dimer.Conclusions: Von Willbrand Factor level was elevated in all patient SD, elevated VWF correlated with elevated D dimer and inversely with oxygen saturation.