The influence of glucose and fatty acids on CXCL10 expression in skeletal muscle cells

Abstract

Chemokine (C-X-C motif) ligand 10 (CXCL10) is a pro-inflammatory cytokine implicated in various inflammatory diseases and metabolic disorders. Skeletal muscle, a primary tissue in glucose and lipid metabolism, plays a critical role in the pathophysiology of metabolic syndrome and type 2 diabetes. This study aims to elucidate the influence of glucose and fatty acids on CXCL10 expression in skeletal muscle cells, providing insight into the inflammatory response mechanism within metabolic diseases.