The possible association of alpha tocopherol and uterine leiomyoma

Abstract

Background: Uterine leiomyomas are noncancerous growths of the reproductive tract that originate from uterine smooth muscle cells. Progesterone and steroid hormones, oestrogen, are regarded as the most crucial elements in the pathophysiology of UFs. Alpha-tocopherol represents the quantum peak of vitamin E's activity. ATs possessing structural determinants, which render them potential ligands for oestrogen receptors (ERs), is crucial with respect to UFs.The purpose of this research was to determine whether serum alpha-tocopherol levels were associated with uterine fibroids.Methods: A case-control investigation was conducted at the Babylon Teaching Hospital specialising in obstetrics and paediatrics from February to November 2019. The present investigation comprises a sample of 100 women. Fifty women diagnosed with uterine fibroids comprise Group A. As a control, fifty women without uterine fibroids comprised Group B. We determined the serum alpha-tocopherol levels of both groups in this investigation. The results were: The levels of serum alpha-tocopherol were compared using the Student's t-test between the two study groups. A statistically significant distinction was observed between the two groups, with cases exhibiting a mean difference of (7.53) μg/mL (11.83±4.50) μg/mL and controls (4.30±1.44) μg/mL (Students’-test = 11.27, d.f. = 98, P-value < 0.001).Conclusion: A strong and statistically significant correlation was observed between elevated levels of AT in the serum and the presence of uterine fibroids. An analysis of serum AT levels revealed no significant correlation between age, BMI, and AT levels.