Isoflurane sparing effect of a multimodal analgesic protocol for ovariohysterectomy in dogs

Abstract

The study was conducted to evaluate the isoflurane sparing effect of a multimodal analgesic protocol in dogs. Twelve animals presented for ovariohysterectomy were selected and divided into group I and II. Group I received gabapentin (2 mg/kg orally), meloxicam (0.1 mg/kg subcutaneously), butorphanol (0.2 mg/kg) and dexmedetomidine (3.5 µg/kg intramuscular), diazepam (0.2 mg/kg), propofol to effect, ketamine (0.7 mg/kg), and lignocaine (2 mg/kg) intravenously, followed by a constant rate infusion of ketamine (10 µg/kg) and lignocaine (30 µg/kg) along with isoflurane maintenance. In Group II, tramadol 2 mg/ kg and dexmedetomidine 3.5 µg/kg intramuscular, followed by diazepam 0.2 mg/kg and propofol to effect intravenously were given. Anaesthesia was maintained with isoflurane in both the groups. The multimodal analgesic protocol provided better quality of sedation and induction, reduced the requirement of propofol for induction and isoflurane for maintenance of anaesthesia and also reduced postoperative pain when compared to a balanced anaesthesia protocol without abnormal deviations from normal.