Effect of ethanolic extract of Petroselinum crispum (Mill.) Fuss (Apiaceae) strand on acetaminophen-induced hepatotoxicity in wistar rat

Abstract

Petroselinum sativum (Apiaceae) plant is used in traditional medicine practice for the management of many pathologies including renal and liver diseases. Therefore, the current study aims to investigate the hepatoprotective effect of Petroselinum sativum (Apiaceae) against acetaminophen hepatotoxicity in rats. To achieve this aim, thirty adult male albino rats were divided into equal five groups as following, Group I, negative control received 0.9% NaCl orally (Control + NaCl); Groups II, Positive control, received acetaminophen solution at 200 mg/kg bw (Acetam. 200), Groups III, IV, and V received acetaminophen solution at 200 mg/kg bw and vitamin E (250 mg/kg bw), Petroselinum sativum strand ethanolic extract at 200 and 400 mg/kg bw respectively. At the end of experiment (after 7 days), blood samples were collected for biochemical and hematologic analysis. Renal toxicity and oxidative stress were observed in untreated paracetamol-intoxicated rats asResult shown the body-weight gain (p