Green synthesis of silver nanoparticles using leaves of Persicaria capitata and their anticarcinogenic activity on liver cancer

Abstract

The next generation of anti-cancer drugs might be made using biological silver nanoparticles (AgNPs). Here, AgNPs were made utilizing Persicaria capitata leaves and a natural process. Several spectroscopic methods were used to confirm the produced and described AgNPs. Thepeak of the AgNPs Surface Plasmon Resonance (SPR) at 424 nm was identified by UV spectroscopic research. Using a transmission electron microscope (TEM), AgNPs were sized and shaped, and it was found that they were 3 nm in size. X-ray Diffraction (XRD) spectrumdata supported AgNPs' crystallinity. A clear, strong signal at 3.0 keV was visible in the EDX spectra, proving that elemental Ag was present. Silver nanoparticles were created, particle size distribution analysis of synthesized Ag nanoparticles was determined by DLS zetasizer. DLS study showed that the biosynthesized silver nanoparticles have size of 194.43 nm with polydispersity index (PDI) of 24.5%. Using a zeta potentiometer, the stability of silver nanoparticles was evaluated. The produced nanoparticles have a zeta potential of -20.9 mV. Using the analytical method FTIR, the functional groups responsible for the synthesis of nanoparticles and the generated AgNPs were identified. AgNPs' anti-cancer efficacy against liver (hep-2) cancer was examined, and its great anti-cancer potential was found. Our results imply that produced AgNPs significantly suppress liver cancer cell (hep-2) formation using the MTT test.