Formulation optimization for controlled release of acetaminophen in matrix tablets

Abstract

The present study reports the influence of Poloxamer 407 polymer on the release kinetics of Acetaminophen (Paracetamol) in matrix tablets. The formulations were developed using excipients such as Poloxamer 407 and Lactose in different ratios. Characterization was carried out by Fourier Transform Infrared (FTIR) Spectroscopy ultraviolet (UV) Spectroscopy, and Differential scanning Colorimetry (DSC). The FTIR and UV studies suggested no bond formation occurred between the polymer and the drug. DSC results ruled out any interaction or complex formation between the drug and the polymer which released the drug over an extended period of more than eight hours. Sustained release tablets were prepared by dry Granulation method. The formulations were subjected to various evaluation parameters such as Drug Excipients compatibility studies, Angle of Repose, Bulk Density, Hardness, Friability, Drug content uniformity, Wetting time, in vitro dissolution studies, and Curve fitting analysis. All the formulations appeared good and showed better physical and mechanical properties. The results indicate that there is no chemical interaction between the polymer and the drug. Based on R-value Formulation follow the zero-order model and Korsmeyer Peppas model showing that the drug is poorly soluble in matrix dosage form. According to the calculation, the n value of all formulations is higher than 0.89. So, these formulations follow the super case II transport Mechanism of release.