Serum kreb von den lungen-6 (KL-6) as a useful biomarker for evaluation of Covid-19 disease severity

Abstract

Aim: The study aimed to investigate the role of KL-6 in severe and non severe Covid-19 patients. Method: In our study, 160 patients with Covid-19 were enrolled after being confirmed by RT-PCR. Estimation of KL-6, C-reactive protein (CRP) and lactate dehydrogenase (LDH) were performed, with comparing their levels in severe and non-severe cases. Study of the relationship between KL-6 and inflammatory marker was carried out by using the Spearman correlations. Results: The results showed an increase in CRP, LDH & Kl-6 levels in the sera of Covid-19 patients, and highly significant increases were observed in their levels in severe patients than in non-severe cases (p= 0.001, p= 0.000 & p= 0.000), respectively. Spearman’s correlation showed significant correlation between KL-6 & inflammation. Conclusion: It can be concluded that KL-6 seems to be a useful biomarker in the prognosis of Covid-19.