Prevalence of fractures among patients suffering from thalassemia

Abstract

Aim: The objective of this investigation was to ascertain the incidence rate of fractures among individuals affected with thalassaemia syndromes.Methods: A retrospective study and patient interviews were undertaken involving one hundred hospitalized thalassaemia patients. The patient interview questionnaire comprised various sections, including inquiries pertaining to fractures, medical history (Including Orthopaedic and surgical procedures), tobacco and alcohol use, and demographic information. Using likelihood ratios, the risk factors for fracture were identified.Results: 35.3 percent of patients with thalassaemia syndromes were affected by fractures. The incidence of fracture was found to be higher among patients with beta thalassemia (44.1%) compared to those with alpha thalassaemia (16%). Fractures most frequently occurred in the upper extremity, with falls and motor vehicle accidents being the leading causes, and casts or splints being the most frequently prescribed treatment. A total of 28% of the patients were found to have multiple fractures. Fracture risk factors among patients with thalassemia included low body mass index, male gender, beta thalassemia, splenectomy, and transfusion.Conclusion: The incidence of fractures is significantly elevated in patients diagnosed with thalassaemia. It was determined that the aetiology was multifactorial.