Subacute toxicity assessment in rats of aqueous extract from Abrus precatorius Leaves (Fabaceae) a medicinal plant used in the treatment of diabetes

Abstract

Abrus precatorius is recognized in traditional medicine for its therapeutic virtues on various diseases such as diabetes. The study consisted of evaluating the subacute toxicity in rats of the aqueous extract of the leaves of A. precatorius. The aqueous extract obtained by the traditional method (Decoction). The subacute toxicity study was carried out for 21 days. The rats (n=12) were distributed into two groups of six. The treated batch receives orally day (Morning / evening) for 7 days at two doses of extract aqueous (ETAAP 40 mg/mL) against the control batch which receives only distilled water. The rats were observed 14 days after stopping treatment and some biochemical parameters related to liver function (Glutamic Pyruvic Transaminase and Glutamic Oxaloacetic Transaminase) and renal function (Creatinine) were sought. The results of subacute toxicity showed that the experimental effective dose of aqueous extract did not cause significant variation of the transaminase and creatinine in normal rats treated against the control group. The study showed no deaths and no clinical signs of toxicity in rats.