Wound healing activity of ethanolic extract of pods (fruit) of Acacia concinna Linn. as a traditional medicine in Wister albino rats

Abstract

In Ayurveda pods of Acacia concinna L. were claimed to possess wound healing potential. The present study was undertaken to evaluate the ethanoic extract of pods of Acacia concinna in the form of an ointment with two different concentrations (5% and 10% w/w ointment of pods extract in simple ointment base) were evaluated for wound healing activity in rats using excision and incision wound model. Both concentrations of the ethanolic extract ointment showed significant responses in both the wound types (excision and incision) when compared with the control group. 5% & 10% ointment of EEAC were applied topically on the wounds of rats and observed wound contraction, percentage of wound closure & period of epithelization, in excision model and tensile strength in incision model. Both 5% & 10% (w/w) extract showed significant wound healing activity by increasing percentage of wound contraction, reducing epithelization period and tensile strength. The wound healing effect was dose dependent. The wound healing activity of EEAC may be due to the phytoconstituents present in extract such as flavonoids, saponins, alkaloids & tannins.