Therapeutic management of canine pyometra by using mifepristone and misoprostol

Abstract

Pyometra is characterized by the accumulation of purulent material within the uterus, which manifests in both local and systemic symptoms. It is typically a post-estrual syndrome in adult female dogs associated with a variety of clinical and pathological manifestations of the genital system and multisystemic disease. The management of canine pyometra using mifepristone along with misoprostol was studied in five female dogs with ultrasonographic and haemato-biochemical profile analysis. All the female dogs recovered at the end of treatment. Endometrium thickness and uterine lumen diameter were significantly decreased in all the animals at the end of treatment. In Hemato-biochemical analysis, TLC value decreased significantly in all the dogs after completion of treatment while AST, ALT and BUN values decreased non-significantly.