Study of serum interleukin 35 level in patients with acute myeloid leukemia

Abstract

Background: Acute myeloid leukaemia (AML) is a dangerous cancer of the blood-forming stem cells, which leads to a rise in the number of myeloid cells in the bone marrow. This may cause severe infections, bleeding, or the invasion of organs, ultimately leading in death. This research aimed to evaluate the significance of serum interleukin IL-35 levels in individuals with AML.Methods: Serum IL-35 was measured using enzyme-linked immunosorbent assays and evaluated as biomarkers for the diagnosis and prognosis.Results: There was positive significant correlation between serum IL-35 level and Age, WBC, peripheral blood blasts, BM blasts, lactate dehydrogenase (LDH), cluster of differentiation (CD) 45, myeloperoxidase (MPO), human leukocyte antigen - DR isotype (HLA-DR) and CD34 (p