In-silico analysis of phylogeny, physicochemical and structural properties of nucleocapsid proteins of Peste des Petits Ruminants virus across India and globally

Abstract

Peste des Petites Ruminants (PPR) is an important livestock disease affect small ruminant productivity especially goats. PPR virus is known to be ssRNA virus and is continuously evolving and mutating which increases infectivity and spread of disease. Phylogenetic analysis, physicochemical and structural properties provide a better base for characterisation of PPR virus. The evolutionary trace back revealed that there are more than one lineage circulating around the world. Physicochemical properties i.e. pI, aliphatic index and GRAVY also differs greatly in all the samples. Homology and structural modelling also differ in its sequence resemble in all nucleocapsid proteins of the virus. Overall, this study provided a snapshot view of representative variants of nucleocapsid proteins around the world.