Synthesis, characterisation and antimicrobial activity of n-substituted 2-thiohydantoin derivatives

Abstract

Novel 2-thiohydantoin derivatives (1a and 1b) were synthesized from aurones with solvent ethanol. The structures of synthetic compounds were characterized using Fourier-transform infrared spectroscopy (FT-IR), 1H-nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. Synthesized compounds shows good to moderate antibacterial and antifungal activities against Bacterial culture, Escherichia coli (MTCC-452), Pseudomonas aeruginosa (MTCC-3541), Mycobacterium tuberculosis (MTCC-300), Enterococcus faecalis, Aspergillus niger, (MTCC-281), Candida. Albicans, (MTCC- 854) species.