Effect of niclosamide ethanolamine on the serum oxidative stress markers in cardiac injury

Abstract

Present study explored potential of anthelmintic niclosamide ethanolamine, known for its antioxidant, and anti-inflammatory properties, in mitigating cardiac injury brought on by isoprenaline. Cardiac injury was induced viasubcutaneous administration of isoprenaline (ISP) @ 20mg/kg body weight for 14 days. Niclosamide ethanolamine was administered @ 3 mg/kg b.w. (intraperitoneally) on alternate days with daily dosing of ISP in the treatment group. Mice were sacrificed on day 15th, and serum samples were used for estimation of oxidative stress parameters in different groups. The study reveals that isoprenaline-induced oxidative stress results in decreased antioxidants coupled with increased lipid peroxidation marked by elevated malondialdehyde (MDA) levels which have been improved by niclosamide ethanolamine administration. In conclusion, niclosamide ethanolamine showed the potential to attenuate the isoprenaline-induced oxidative stress, suggesting its role in limiting the progression of cardiac injury via its antioxidant ability.