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Abstract

Objective: To study antibiotic sensitivity and resistance pattern from sputum/tracheal swab of patients on ventilatory support in ICU of tertiary care hospital.Method: A prospective observational study was carried out based upon the reports of bacterial isolates from ICU of Dept. of Medicine, Govt.Medical College and Hospital, Aurangabad between "23 October, 2017 to 28 February, 2018".56 patients were studied.Susceptibility testing was performed using disk diffusion method.The results were interpreted according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI). Results:The study revealed the presence of Klebsiella species in 28.29% (n=26) samples followed by Pseudomonas aeruginosa 20.69% (n=18), Klebsiella Pneumonia 13.79% (n=12), Acinetobacter baumannii 10.34% (n=9), Non-fermenting gram negative rods 9.19% (n=8), respectively.A high range of resistance was seen for Ceftazidime in case of Klebsiella spp (91.66%).Overall Colistin was the most sensitive drug among all group of microorganisms. Conclusion:The present study is an initiative to observe serious threats in patients admitted in ICU due to nosocomial infection.Most com monest microorganisms observed were Klebsiella species 28.29% (n=26), Pseudomonas aeruginosa 20.69% (n=18), Klebsiella pneumonia 13.79% (n=12), Acinetobacter baumanni 10.34% (n=9).Maximum resistance was observed to Ceftazidime, 3 rd generation cephalosporin 92.7% (51 out of 55).Highest sensitivity was seen for Colistin (80%) followed by Ciprofloxacin (76.8%).Such studies will restrict emergence of resistant bacteria, effective cost benefit, inventory and stock management.