Antimicrobial study of some Ganoderma species against gram-positive bacterial isolates of diabetic foot ulcer

Abstract

Ganoderma (Ganodermataceae) is known for its therapeutic applications. Its species such as G. applanatum, G. boninense, G. lucidum, G. resinaceum and G. tsugae, are known for their specific biologically active and macromolecules such as polysaccharides, triterpenoids, steroids, phenolic compounds, lipids and alkaloids revealing its vast biomolecular diversity. The antimicrobial studies of these species was carried out against some Gram positive bacterial isolates of diabetic foot ulcer. In present study, the antibacterial and inhibitory effects of various Ganoderma extracts in petroleum ether, chloroform, acetone, ethanol, methanol and aqueous were used against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Enterococcus faecium and Streptococcus pneumoniae by agar well diffusion method. All the extracts exhibited various degree of inhibition against all tested bacteria. G. applanatum and G. tsugae shown the best results against Gram positive test bacteria and therefore, represent a good model for the development of new drug formulations for diabetic patients.