Histopathological and Immunohistochemical evaluations of canine cutaneous epithelial tumors

Abstract

The present study was conducted to investigate the histopathological findings and immunohistochemical expression of Cytokeratin, Proliferating Cell Nuclear Antigen in canine cutaneous epithelial tumors. In this study, two cases each of Squamous Cell Carcinoma, Hepatoid gland adenoma, Sebaceous gland carcinomas and 3 cases of Basal Cell Carcinoma, were included. Strong to moderate expression of Intracytoplasmic immunoreactivity for Cytokeratin observed in all cases and Strong nuclear immunoreactivity for proliferating cell nuclear antigen observed in Poorly differentiated Squamous Cell Carcinoma compared to well differentiated Squamous Cell Carcinoma. Strong nuclear immunoreactivity for Proliferating Cell Nuclear Antigen observed in Basal Cell Carcinoma and sebaceous gland carcinoma. In heapatoid gland adenoma moderate Nuclear immunoreactivity for proliferating cell nuclear antigen observed. In this study, besides histopathology, effective systematic use of Cytokeratin, Proliferating Cell Nuclear Antigen confirmed the epithelial origin of tumors and helps in evaluating the proliferation rate.