Evaluation of CDX2 expression and correlation with histopathological grading of Colorectal Carcinoma

Abstract

Background: Colorectal cancer is the third most commonly diagnosed cancer in male and second in female and third most common cause of cancer death in the world. Only histopathological diagnosis is not always sufficient to predict the clinical outcome and prognosis of colorectal carcinoma. So, it is an emerging need to use specific immunohistochemical stains. CDX2 is a prognostic indicator of colorectal carcinoma. This study focuses on association of CDX2 with grading of colorectal carcinoma. Materials and Methods: Fifty-one surgical specimens of large intestine were included in this cross-sectional study conducted in Sir Salimullah Medical College from July 2019 to June 2021. Specimens were processed routinely for Haematoxylin and Eosin followed by immunohistochemistry for CDX2. Histopathological and immunohistochemical results were analyzed. Statistical analysis was done using Statistical Package for Social Sciences version 22. Observation and results: Among 51 histopathologically diagnosed colorectal carcinoma cases 11 were well differentiated adenocarcinoma, 28 were moderately differentiated adenocarcinoma and 12 were poorly differentiated adenocarcinoma. CDX2 expression is gradually decreased with increase of WHO grading. These association was statistically significant (p