Synthesis and biological investigation of novel heterocyclic thiosemicarbazone silver (I) complexes as potent antimicrobial agents

Abstract

Herein, new heterocyclic thiosemicarbazone silver (I) complexes (Tsc1, Tsc2, Tsc3, Tsc4) were synthesized by the template method, and their structures were determined using some spectral techniques: element analysis, Fourier transform infrared spectra (FT-IR), proton nuclear magnetic resonance (1H-NMR), thermogravimetric analysis (TG-DTA), organic elemental analysis, and magnetic susceptibility measurements. The biological activities of the newly synthesized heterocyclic thiosemicarbazone silver (I) complexes were investigated as potent antimicrobial agents against some disease-causing pathogens. For this purpose, the well-diffusion method was used. The biological activity results demonstrated that all novel heterocyclic thiosemicarbazone silver (I) complexes have high or moderate inhibitory activity of the tested pathogenic strains. Graphical Abstract