Protective effects of hesperidine against organ toxicity and oxidative stress induced by piroxicam in wistar rats

Abstract

The present study was carried out to evaluate protective effects of flavonoid Hesperidine against pathological effects and oxidative stress induced by Piroxicam. Forty Wistar rats were divided into five groups namely vehicle control, low dose toxicity control, high dose toxicity control, protective group for low dose toxicity and protective group for high dose toxicity. At the end of an experiment, gross and microscopic examination of liver, kidney, intestine and stomach was done and oxidative stress was also measured. In piroxicam high dose group, gross examination of liver, kidney, stomach and intestine released inflammation, gastric erosions and ulcers, intestinal necrosis and erosions as well as degenerative/necrotic and/or inflammatory changes Where’s the SOD values decreased and LPO was increased significantly. However, pathological changes in organs as well as oxidative stress were considerably found reduced which were produced by piroxicam high dose. According to the present findings, hesperidine protected the organs like liver, kidney and intestine as well as stomach it also showed promising antioxidant activity.