The potential ameliorative role of naringenin against 5-Fluouracil induced nephrotoxicity toxicity

Abstract

5-Fluouracil-induced nephrotoxicity causes alterations in renal markers and kidney morphology by increased oxidative stress, inflammation and apoptosis play an important role in the pathogenesis of kidnry injury. The present study was assessed to mitigative action of naringenin (NG) powder in 5-FU induced toxicity. We divide forty eight animals into 4 groups (n=12) and sacrificed on 14th and 28th day and reported that NG treatment significantly decrease in blood urea nitrogen-BUN and creatinine value, lipid peroxidation and inflammatory markers - tumour necrosis factor (TNF-α), interleukin -1β (IL-1β), Nuclear factor Kappa beta (NF-κB) with increased concentrations of interleukin-10 (IL-10), albumin along with increase in endogenous antioxidant enzymes-superoxide dismutase (SOD) and glutathione peroxide (GSH). In addition to theses, histological alterations also clarified that 5-FU induced distorted renal corpuscles and tubules with inflammatory cell infiltrations and severe congestion were decreased by NG treatment. Our results suggest that NG have ameliorative action against 5-FU induced nephrotoxicity, however, NG on 28th day much better results than 14th day in all parameters.