Effect of levofloxacin on liver biochemical parameters following repeated oral administration in dual purpose chicken

Abstract

Levofloxacin, a third-generation fluoroquinolone, is the S-isomer of ofloxacin and possesses excellent activity against gram-positive, gram-negative and anaerobic bacteria. The experimental birds (35 day old) were randomly allotted into three groups (n=30), Group I birds served as control (Distilled water), Group II and Group III birds were administered with levofloxacin at the dose rate of 10 mg/kg bw and 20 mg/kg bw respectively for five days directly into the crop using a thin plastic tube attached to a syringe for 28 days. The food was withheld for 12 h before oral dosing but not water and water was provided ad libitum before the drug administration. The serum samples were used for the determination of AST. ALT and Alkaline Phosphatase biochemical parameters on day 0, 7, 14, 21 and 28. There was a significant increase (p