Wharton jelly mesenchymal stem cells: A potential candidate for neuronal trans-differentiation

Abstract

The nerve injury, whether it results in tissue loss or not, involves cutting off the nerve, making it impossible for the two portions to interact and, as a result, impairing functionality. Mesenchymal stem cells are one of the best options for cell therapy in many diseases due to their distinct functional properties, such as their potent differentiation capacity, immunomodulatory capacity and growth support. The secretome generated by WJ-MSCs is a key factor in their transdifferentiation into neural stem cells. These cells provide a favorable environment for damaged nerves to regenerate by secreting chemicals that nourish, protect, and activate both neuronal and non-neuronal cells involved in the process. The combination of these properties can accelerate nerve regeneration processes and improve functional recovery.