The effect of two different doses of Dexmedetomidine infusion on oxygenation, lung mechanics and quality of recovery in morbidly obese patients: A prospective randomized study

Abstract

Background: Restrictive lung disease affects the majority of morbidly obese individuals. This study compared the effects of two separate amounts of dexmedetomidine infusion on oxygenation as the main result and on lung mechanics, quality of recovery, and postoperative pain relief as secondary results in morbidly obese individual with restrictive lung disease getting laparoscopic abdominal surgery.Methods: Ninety individuals who were morbidly obese participated in this prospective randomized research. Patients were divided into 3 equal groups randomly. Following a 10-minute intubation of the endotracheal tube, the DEX 0.6 and 0.3 groups received a bolus dose of 1 g/kg Dexmedetomidine 15 minutes later, accompanied by an hour-long infusion of 0.6 and 0.3 g/kg/hr, correspondingly. The control group got a similar amount (0.9%) of ordinary saline. P/F ratio, lung mechanics quality of recovery and perioperative analgesic consumption were recorded.Results: In comparison to the control group, Dex groups had increased P/F ratios for both static and dynamic compliance. In comparison to the control group, both Dex groups had reduced levels of dead space, the sedation agitation scale, intraoperative fentanyl intake, pain evaluations, morphine usage, and postoperative nausea and vomiting. In comparison to the Dex 0,3 group and the control group, the problems related to hypotension and bradycardia were more common in the Dex 0,6 group. Also, QOR 15 were better in both Dex group compared to control group.Conclusions: Two separate dosages of dexmedetomidine infusion at rate of 0.6 and 0.3 mic/kg/hr were shown to enhance lung mechanics and oxygenation, pain after surgery evaluations, analgesic usage, and recovery quality among morbidly obese individuals with restrictive lung disease. Dex 0.3, however, maintained hemodynamics.