Prognostic value of copeptin and sequential organ failure assessment score in toxin linked acute respiratory distress syndrome

Abstract

Background: Acute poisoning with breathing and pulmonary complications is a common cause of admission to emergency departments and often needs treatment in the intensive care unit. Aim: This study aimed to evaluate the prognostic value of copeptin level and sequential organ failure assessment score (SOFA) as predictors in toxin-linked acute respiratory distress syndromeMethods: This is a prospective cohort study. Human serum copeptin level was assayed using a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) to assay the level of human copeptin in samples and the severity of the cases was evaluated by SOFA score. Results: Several variables were associated with poor outcome in the poisoned acute respiratory distress patients like delay time between toxicity and hospital admission, conscious level, arterial blood gases with highest significance to copeptin level. Analysis of receiver operating characteristics curves of serum copeptin level as a predictor for toxin-linked ARDS showed that copeptin had an area under curve equals 0.913 with a sensitivity 90% and specificity 75% with cutoff level 1.081 Pmol/L.Conclusions: Early combination of plasma copeptin and SOFA scores could help in identifying patients at risk of severe fatal toxin – related ARDS.