High serum lactate dehydrogenase levels as a prognostic marker for morbid perinatal outcome in pre eclampsia

Abstract

Introduction: Hypertension during pregnancy is an important causative factor of perinatal and maternal morbidity and mortality globally. There are several biochemical markers like ALP, AST, ALT, LDH, Uric acid to ascertain the severity of disease. The aim of our study was to determine the effectiveness of lactate dehydrogenase as a prognostic marker in assessing the sequalae of preeclampsia. Materials and Methods: This analysis was conducted at RMMCH in the Department of OB-GYN for a period of 2 years (2016-2018). It was a prospective case control study. A total of 60 antenatal mothers were included in the study, of which 30 were healthy pregnant females and 30 were pre eclamptics. Results: The mean values of serum LDH levels were found to be high in preeclamptics compared to normotensives which was significant statistically (p value of < 0.001). Adverse perinatal effects were seen in females with raised LDH levels (p value of