Studies of transition metal (II) complexes with β-lactam ring

Abstract

The complexes of Ni (II) and Cu (II) with β-Lactam-amoxicillin have been synthesized. The structures of these newly synthesized complexes were substantiated by elemental analysis, molar conductivities, infrared, electronic absorption spectra and magnetic moment measurements. On the basis of these analyses it has been confirmed that direct reaction of metal salts with amoxicillin-suspension leads to formation of complexes. The tridentate nature of ligand and square planar geometry of the complexes has been established. The ligation centers of the amoxicillin as NH2, NH and hydroxyl groups have also been confirmed. Solubility of the complexes has been determined by using different solvents. Melting point of the complexes was determined by the open capillary tube and hence is uncorrected.