Role of YKL-40 in cutaneous and systemic diseases

Abstract

YKL-40 is a glycoprotein that is formed by several types of cells that include immune, tumor, and stromal cells, and has growth factors and cytokines properties. Its exact function is not yet completely clear. It had been found markedly increased in the serum of individuals with various cutaneous and systemic inflammatory diseases suggesting a possible role in their development. Additionally, the degree of severity of the disease coincided with the blood levels of this protein. It may thus be regarded as one of the most useful indicators to assess the level and severity of inflammation in different disorders. Additionally, YKL-40 was found to be expressed by tumor-associated macrophages and several cancer cell types. Several study's findings indicated a substantial connection between YKL-40 and the development and propagation of cancer. As a result, it was thought that YKL-40 might be useful as a marker for the development of cancer and the patient's reaction to the applied drugs.