A prospective study on role of tranexemic acid in reducing post-operative blood loss in TKR

Abstract

Introduction: In total knee arthroplasty’s 2 types of blood loss will be seen one which is visible in surgical field other being blood loss into tissues (hidden). Use of tourniquet limits the perioperative bleeding it increases fibrinolysis activity and post operatively due to tissue trauma fibrinolytic system is activated contributing to post-operative blood loss. Tranexamic acid {TEA} is a synthetic fibrinolysis inhibitor. Studies show that Tranexamic acid given intravenously acts for up to 3 hours. The aim of this study is to determine the efficacy of Tranexamic acid given in single bolus to decrease post-operative blood loss.Materials and Methods: Prospective study from January 2021 to November 2021 over a period of 1 year with 40 patients diagnosed with bilateral osteoarthritis of knee. All surgeries were performed by same surgeon using same surgical technique. DT (drain tube) used postoperatively to record the post-operative blood loss on POD 0 AND POD 1. Results: A total of 40 patients with mean age of 57 yrs. Mean duration of surgery was 93min (ranging from 100 to 120 min)mean tourniquet time being 83.6 min, mean post-operative blood loss was 188 on POD 0 38 ml on POD 1 showing significant decrease in blood loss after Tranexamic acid injection (p