Acute respiratory distress syndromе

Abstract

The article provides data proving the toxic nature of the respiratory parenchyma lesions of the lungs during acute respiratory distress syndrome development. They determine the severity of the disease until death, which can’t be prevented by drug therapy or various methods of mechanical ventilation, up to extracorporeal membrane oxygenation. The accumulation of large molecular toxic products unable to be excreted by the kidneys is the indication for extracorporeal detoxification. Moreover, using hemosorption, it is possible to remove not only toxic substances but pathogens as well. Subsequent plasma exchange in addition to detoxification leads to the body's immune defense restoration due to the removed plasma replacement with freshly frozen donor plasma. The experience of treating 153 patients with varying ARDS severity stages confirms the need to use extracorporeal detoxification and immunocorrection methods in its treatment.