Intra-cerebrospinal fluid chemotherapy is new direction in pediatric solid tumors in developing countries

Abstract

Introduction: Intra-cerebrospinal fluid (CSF) chemotherapy defined chemotherapy drugs administration in the brain/spine fluid compartment for leptomeningeal metastases treatment in infilterative tumors such as leukemia and lymphoma routinely. This method was administered for adults since 20 years ago but there is a limited experiences in children. Material and Method: We used electronic search on the online medical database "Pubmed" and other motor search-engines such as "Google Scholar” and selected all of articles about intra-CSF chemotherapy regimens in solid tumors. Results: We collected original articles and review articles over 20 years, on the target. All of selected articles include intratechal chemotherapy regimens in solid tumors in pediatrics and adult patients with leptomeningeal metastasis. Conclusion: We introduce several intra-CSF chemotherapy regimens in solid tumors.These approach can be used in pediatrics with radiation limitation.