Honey: A remedy for depression. An investigation by experimental validation and molecular docking studies

Abstract

Depression also known as clinical depression, is a mental disorder of public health concern that should be properly and immediately treated because a poor medical follow up can lead to suicide resulting to death or major body self-infliction of harm. Prediction of the phytochemical compounds in honey on neurotransmitters and enzymes involved in depression were investigated by in-silico studies. This research was done to create docking scores, predict pharmacodynamics of honey and to identify the potential oral drugs used for the treatment of depression Studies have shown that honey and related by products like propolisto be very useful in the treatment of depression. In this preclinical research, animal models was used to demonstrate the antidepressant effect of honey on female albino mice. These tests included tail suspension test and forced swim test, during which they were shared into four groups. From the results obtained honey showed a promising antidepressant activity together with a better synergism with imipramine.