Hypoglycemic activity on Putranjiva roxburghii bark. in alloxan induced diabetic rats

Abstract

Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic angiopathy retinopathy, neuropathy nephropathy, and causing neurological disorders due to anxiety in utilization of glucose. I present diabetes study was induced in albino rat models with the alloxan monohydrate. Putranjiva roxburghii bark. has been claimed to possess antidiabetic properties by some investigators. The present study was undertaken to screen the hypoglycemic activity of ethanol extracts of leaves of Putranjiva roxburghii. The results showed that it has significant anti-hyperglycemic effect in experimental model of diabetes mellitus.