The effects of lutein and zeaxanthin (Lute-genandreg;) supplementation, with and without natural mixed carotenoids on macular pigment optical density in healthy adult subjects: A randomized, double-blind, placebo-controlled study

Abstract

Levels of the macular xanthophylls lutein, zeaxanthin and other carotenoids have been associated with slower progression of age-related macular degeneration potentially through their action by quenching reactive oxygen species, scavenging blue light and thereby protecting the eye from photo-oxidative damage. The objective of this clinical study was to assess the effect of Lutein and Zeaxanthin (Lute-gen®) supplementation, with and without natural mixed carotenoids on macular pigment optical density (MPOD) in healthy adult subjects. A total of 93 subjects were randomized in a double blind, placebo controlled, parallel, three arm study which was followed up for 180 days. Subjects who met the inclusion criteria underwent general physical and ophthalmic examinations. Further, study specific macular pigment optical density (MPOD) was assessed through macular assessment Profile (MAP) test. Data obtained post study period were subjected to advanced statistical analysis to determine efficacy of Lutein and Zeaxanthin (Lute-gen®) with and without natural mixed carotenoids on macular pigment optical density (MPOD). Lutein and Zeaxanthin (Lute-gen®) supplementation, with natural carotenoids (P=0.0009) and without natural mixed carotenoids (P=0.0001) showed statistically significant improvements in the MPOD levels when compared to baseline from the last visit. On the other hand, the placebo arm (P=0.6179) did not show any significant change in MPOD levels. It can be concluded that higher levels of MPOD may reduce the risk of age-related macular degeneration (AMD) and provide necessary protection against oxidative damage and blue-light.