Study of characteristics of intracavitary uterine pathologies among perimenopausal and postmenopausal women presenting with abnormal uterine bleeding

Abstract

Objets: Study of clinical and para-clinical characteristics of intracavitary pathologies in peri-menopausal and post-menopausal women with abnormal uterine bleeding (AUB). Materials and methods: This was a prospective observational study and included 150 women above 40 years-old with AUB and had histopathological results to compare. Results: A mean age of total study was 51.51 ± 7.65. The most common symptom of AUB in perimenopause women was menorrhagia, making up to 62.2% of cases. There were 54.7% of cases had at least one functional symptom associated besides AUB, frequent symptoms were pale skin (35.9%) and hypogastric pain (31.3%). Prevalence of intracavitary pathologies differentiated from age, the most common abnormalities in peri-menopausal bleeding women are endometrial hyperplasia (66.7%), in post-menopausal bleeding women were endometrial hyperplasia (51,7%) and endometrial cancer (EC) (38,3%). Women with peri-menopausal bleeding had moderate-severe anemia (58.1%) was greater than women with post-menopausal bleeding (10.0%). The most common anormality resulting in severe anemia was endometrial hyperplasia (70.8%), EC occupied only 4.2%. Our study revealed age, diabetes in relationship to malignant disease. Others factors were less associated With malignancy. Size of uterus was different between the benign and malignant group in post-menopausal women with AUB. Dimension of lesion mass was also different among intracavity pathologies. Conclusion: Menorrhagia was the most common type of uterine bleeding caused severe anemia in perimenopausal women. Endometrial hyperplasia was the most popular cause lead to menorrhagia in intracavitary abnormalities. Age, diabetes increased the risk for EC. Size of uterus and intrauterine mass had association with malignant lesion in postmenopause with AUB.