Analgesic potentials of aqueous leaf extracts of Jatropha Tanjorensis and Cnidoscolus aconitifolius on Wistar rats

Abstract

This study investigated the analgesic potentials of aqueous leaf extracts of Jatropha tanjorensis (JT) and Cnidoscolus aconitifolius (CA) on Wistar rats. Hot plate and writing methods were used to ascertain pain. Hot plates test consist of 8 groups; control, 200mg/kg celecoxib, 50mg/kg Diclofenac, 500mg/kg JT, 500mg/kg CA, 1000mg/kg JT, 1000mg/kg CA and a combination of 500mg/kg each of JT and CA labeled Groups 1-8 respectively. Acetic acid test consist of 6 groups; control, 200mg/kg Celecoxib, 50mg/kg Dichlofenac, 500mg/kg JT, 500mg/kg CA, a combination of 500mg/kg each of CA and JT as Groups 1-6 respectively. Phytochemical screening of CA revealed the presence of alkaloids (4.57%), tannin (0.38%), saponins (3.93%), flavonoids (2.38%), cyanogenic glycoside(0.71%), terpenoid (4.80%), resin(4.75%) and JT revealed the presence of alkaloids(3.59%), tannin (0.65%), saponins (2.73%), flavonoids (3.6%), cyanogenic glycoside (1.16%), terpenoid (3.50%), Resin (3.45%). Result of analgesic potentials showed that JT at 500 and 1000mg/kg significantly (p