Analytical method development and validation for the estimation of nimodipine in pure and marketed formulation by UV-Spectrophotometric method

Abstract

A Simple, specific, rapid, precise and accurate UV Spectrophotometric method was developed and for the estimation of Nimodipine in tablet dosage form. The optimum conditions for the analysis of the drug were established.The wavelength maxima for Nimodipine was found to be 239nm.Beer’s law was obeyed in the concentration range of 5-25μ g/ml having line y=0.033x+0.021 with correlation coefficience of 0.9995.The slope, intercept, correlation coefficient, detection and quantization limits were also calculated. Results of the analysis were validated satistically and by recovery study. The proposed method can be applied for the routine analysis of Nimodipine from the tablet formulation.