Categorization of reproductive hormone profile abnormalities in women with infertility: A retrospective study

Abstract

Objective: To review the pattern of reproductive hormone abnormalities among women with infertility at Bingham University Teaching Hospital. Method: A retrospective review of the patients who had hormonal assay done as part of their infertility workup from January 2021 to December 2022. Results: During the period of the study, there were132 women who had hormonal assay done. Of the 132 women, 50(37.9%) women had abnormal hormonal profile. Normogonadotrophic normogonadism occurred in 41(82.0%) of all the patients, while hyper-gonadotrophic hypogonadism occurred in 6(12.0%) and hypogonadotrophic hypogonadism occurred in 3(6.0%) of the patients. Sixteen (32.0%) had decreased progesterone suggesting luteal phase deficiency, and 21(42.0%) had hyperprolactinemia (Increased prolactin levels). Conclusion: The commonest reproductive hormone abnormalities in our facility are normogonadotrophic anovulation (distorted LH/FSH ratio often caused by polycystic ovary disease), hyperprolactinemia, and luteal phase defect. This is important as these women can be adequately counseled and their infertility managed medically even in our environment, while those with hypergonadotrophic hypogonadism, hypogonadotrophic hypogonadism can be counseled appropriately for assisted reproductive techniques (ARTs).