Raman spectroscopy analysis for monitoring of chemical composition of aspirin after exposure to plasma flame

Abstract

Raman spectroscopy method was optimised to examine the chemical changes of the aspirin tablets after interaction with a helium temperature. Several aspirin tablets were exposure to plasma assisted desorption ionisation flame by different times (10, 30, 50, 60, 180 and 300 seconds) and then analysed by Raman spectroscopy using the optimal conditions. The changes in chemistry between exposed tablets and fresh tablet (without exposure to plasma) were compared. The vibration peaks of aspirin molecule in the Raman spectrum were identified by checking the peak position. The results showed clear spectra with increasing in intensity of vibration peaks until 30 seconds, whereas no spectra were measured for the exposed tablets to plasma flame after 50 seconds. It can therefore, assumed that the chemistry structure of aspirin compound might be damaged by exposing to high temperature.