In vitro anti-cancer, anti-inflammatory and anti-oxidant studies of novel oxazine derivatives

Abstract

The ability to inhibit oxidative stress has been established as the prime mechanism in treatment of several disease conditions. Condensation of substituted acetophenones and Ferrocene aldehyde resulted in the formation of various Chalcones (I-III). The resulting various Chalcones (I-III) react with urea to form various oxazines ((Ia-IIIa). The reaction was monitored by TLC and synthesized products were characterized by physical, Elemental analysis, Spectral studies UV, FT-IR, C13 and 1H-NMR Spectroscopy. When these compounds were screened for antioxidant susceptibilities by FRAPAssay, anti-inflammatory and anti-cancer activities.