Solubility enhanced Nevirapine and it’s use in various forms

Abstract

The aim of present study was solubility enhancement of nevirapine by using different solubilization methods like solid dispersion, hydrotropy and micellar solubilization. Solubility of nevirapine as pure drug and in other forms such as physical mixture, solid dispersions were analyzed using different carriers. Hydrotropic and micellar solubilization techniques were performed with variable concentrations of surfactants. Neviapine solubility enhancement was found to be in the order of micellar solubilization >hydrotropic solubilization > solid dispersion. Increasing the concentration of the solubilizer increased the solubility of the drug. Sodium lauryl sulphate enhanced the solubility of nevirapine to greater levels when compared to other solubilising agents.