Evaluation of antipyretic activity of Echinometra mathaei from sabang nanggroe aceh darussalam

Abstract

The potential of marine resources that have not been much explored is sea urchin (Echinometra mathaei), which is shown to have high antioxidant activity. High antioxidant activity has a potential correlation with analgesic, antipyretic and anti-inflammatory activities. The study aims to determine the antipyretic activity of Echinometra mathaei (EM) in Balb/c mice as an animal model. This study consisted of the extraction of EM with 70% ethanol and antipyretic activity assay on albino mice which induced 10% peptone (s.c). Thirty albino mice were divided into 6 groups i.e: negative control group, positive control group, paracetamol group, extract EM 100mg/kg BW, extract EM 200mg/kg BW, extract EM 400mg/kg BW. The body temperature was observed for 1 h after extract was given p.o. The results showed that all the dosage of EM extract could reduce the elevated body temperature of the mice and the doses of 200 mg/kg BW and 400 mg/kg BW showed no significant difference with paracetamol 65 mg/kg BW (P < 0.05). Conclucion of the research was the extract of Echinometra mathaei has antipyretic activity at the doses of 100 mg, 200 mg, and 400 mg/Kg BW.