Review on role of urea and thiourea derivatives of some heterocyclic Scaffold in drug design and medicinal chemistry

Abstract

Compounds comprising urea and thiourea are progressively more used in drug design and medicinal chemistry to facilitate key drug-target communications and fine-tune crucial drug-like properties. Urea and thiourea represent privileged structures in medicinal chemistry. Certainly, these scaffolds encompass a common structure of a array of drugs and bioactive compounds artistic with a expansive range of beneficial and pharmacological properties. Herein, we provide an overview of urea and thiourea based medicinally important compounds, ranging from standard drugs to current medicinal chemistry developments.