Identification and characterisation of lornoxicam (non-steroidal anti-inflammatory drug)

Abstract

Lornoxicam is a non-steroidal anti-inflammatory drug of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and parenteral formulations. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that particularly explains the pronounced efficacy of the drug. Lornoxicam's anti-inflammatory and analgesic activity is related to its inhibitory action on prostaglandin and thromboxane synthesis through the inhibition of both COX-1 and COX-2. This leads to the reduction of inflammation, pain, fever, and swelling, which are mediated by prostaglandins. However, the exact mechanism of lornoxicam, like that of the other Non-steroidal anti-inflammatory drugs (NSAIDs), has not been fully determined. In this article authors had discuss about the preformulation study.