Comparative study of serum free light chain assay and urine protein immunofixation in the diagnosis of patients with monoclonal gammopathy

Abstract

Serum protein electrophoresis and urine protein immunofixation (IF) are biological techniques for the diagnosis and monitoring of hematological malignancies. The advent of serum free light chain (FLC) assay has provided a new diagnostic element for monoclonal gammopathies. The study conducted in the medical biology laboratory of the Cheikh Zaid University Hospital in Rabat between 2020 and 2022 showed that the determination of serum free light chains (FLCs) provides more critical and accurate information for both the diagnosis and monitoring of hematological malignancies such as light chain myeloma.