Vaginal misoprostol versus dinoprostone before copper IUD application in women with anticipated difficult loop application

Abstract

Background: Intrauterine device (IUD) are safe, reliable and highly effective forms of long-acting reversible contraception. (1) The major advantage of LARC compared with other reversible contraceptive methods is that they do not require ongoing effort on the part of the patient for long-term and effective use. In addition, after the device is removed, the return of fertility is rapidAim and Objectives: The aim of this study was to compare the effect of Vaginal Misoprostol versus vaginal Dinoprostone to facilitate loop application in women with anticipated difficult loop application.Subjects and Methods: About 270 of women were assessed to select of 100 women were randomized to two groups using simple randomization and classified into: Group A: (Misoprostol group): Include 50 patients who received one tablet (200mcg misoprostol in posterior fornix of vagina 3 to 4 hour before IUD insertion.Group B: (Dinoprostone group): Include 50 patients who received one tablet (3mg dinoprostone in posterior fornix of vagina 3 to 4 hour before IUD insertion.Result: Side effect between two study drugs there is more side effects in group A (Misoprostol) than group B (Dinoprostone)but there is no significant difference between two group p value in all side effect is >0.05. Significance difference between two studied group regarding to satisfaction level p value s.002 where p value >0.05Conclusion: Both Dinoprostone and Misoprostol were effective in decreasing pain and easing insertion of Copper IUD in women with anticipated difficult insertion. However, more satisfaction lesser, adverse effects in dinoprostone group, we recommend misoprostol as is less cost than dinoprostone and stable at room temperature. This study further supports the clinical using of dinoprostone in an additional-obstetric indication.