Effect of Citrus maxima (Shaddock) fruit juice on some oxidative stress parameters in CCl4 induced oxidative stress in wistar rats

Abstract

This study was designed to evaluate the in vivo anti-oxidative stress potentials of Citrus maxima juice. Thirty six wistar rats were divided into nine groups. Group 1 served as the normal control. Groups 2-5 which served as the protective study groups were treated from day 1 to 14 of experiment, and administered Carbon tetrachloride on days 13 and 14. Groups 6-9 served as the curative study groups and were administered Carbon tetrachloride on days 0 and 1 of the experiment and treated from day 1 to 14. All animals were sacrificed on the 15th day after a 14-16 hour overnight fast and blood sample collected through ocular bleeding for biochemical analyses. Intoxication with Carbon tetrachloride decreased significantly (p>0.05) the activities of the antioxidant enzymes - Superoxide dismutase, Gluthatione peroxidase and Catalase. Administration of CMJ increased non-significantly (p>0.05) the activities of the antioxidant enzymes.